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presumed ocular histoplasmosis syndrome
Presumed ocular histoplasmosis syndrome (POHS) is a syndrome affecting the eye, which is characterized by peripheral atrophic chorioretinal scars, atrophy or scarring adjacent to the optic disc and maculopathy.
The loss of vision in POHS is caused by choroidal neovascularization.
==Causes==
Despite its name, the "presumed" relationship of POHS to ''Histoplasma capsulatum'' is controversial.〔Thuruthumaly, C; Yee, D. C.; Rao, P. K. (2014). "Presumed ocular histoplasmosis". Current Opinion in Ophthalmology 25 (6): 508–12. doi:10.1097/ICU.0000000000000100. PMID 25237930〕〔Nielsen, J. S.; Fick, T. A.; Saggau, D. D.; Barnes, C. H. (2012). "Intravitreal anti-vascular endothelial growth factor therapy for choroidal neovascularization secondary to ocular histoplasmosis syndrome". Retina 32 (3): 468–72. doi:10.1097/IAE.0b013e318229b220. PMID 21817958〕 The fungus has rarely been isolated from cases with POHS,〔() Presumed Ocular Histoplasmosis Syndrome〕 the condition has also been found in locations where histoplasmosis is rare, and there appears to be a relationship with tobacco smoking.
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